Chronic Obstructive Pulmonary Disease

 

Chronic Obstructive Pulmonary Disease (COPD) Is an umbrella term used to describe progressive lung diseases including emphysema, chronic bronchitis, refractory (non-reversible) asthma, and some forms of bronchiectasis. This disease is characterized by increasing breathlessness.


Many people mistake their increased breathlessness and coughing as a normal part of aging. In the early stages of the disease, you may not notice the symptoms. COPD can develop for years without noticeable shortness of breath. You begin to see the symptoms in the more developed stages of the disease.

COPD can cause coughing that produces large amounts of mucus (a slimy substance), wheezing, shortness of breath, chest tightness, and other symptoms.


Cigarette smoking is the leading cause of COPD. Most people who have COPD smoke or used to smoke. Long-term exposure to other lung irritants—such as air pollution, chemical fumes, or dust—also may contribute to COPD.


How can Stem Cells Help Chronic Obstructive Pulmonary Disorder (COPD)?

Adipose Stem Cell Therapy Is a new alternative treatment to help manage the complications of COPD. The stem cells have the potential to replace countless cells of the body, lung tissue included. These Stem Cells may heal the body by replacing ones plagued with disease, regenerating new cells, and suppressing the immune systems macrophage response which engulf and digest the dying cells of the lungs. Current research in adult stem cell therapy has shown that restoration of damaged cells through this treatment is possible. This breakthrough in regenerative medicine shines a light of hope on those battling this degenerative disease. Improvements have been seen in the following symptoms after treatment:

  • Reduction of dyspnea (difficult or labored breathing)
  • Increased energy
  • Increase in the ability to walk alone
  • Increase in the ability to perform daily tasks
  • Reduction of reliance on supplemental oxygen
  • Improvements in sleep patterns
  • Enhanced mood

Which Kinds of cells are used in Chronic Obstructive Pulmonary Disorder and how are they obtained?

Adult stem cells are obtained from itc bank from donor tissue or autologous transplant, which is harvested from the patient’s own adipose tissue and it takes 21 days to culture, differentiate and administer the adult stem cells to the patient.


Weiss, D., Casaburi, R., Flannery, R., LeRoux-Williams, M., & Tashkin, D. (2013). A Placebo-Controlled, Randomized Trial of Mesenchymal Stem Cells in COPD. Chest, 143(6), 1590-1598. http://dx.doi.org/10.1378/chest.12-2094


Ribeiro‐Paes, J., Stessuk, T., Marcelino, M., Faria, C., Marinelli, T., & Ribeiro‐Paes, M. (2014). A protocol proposition of cell therapy for the treatment of chronic obstructive pulmonary disease. Revista Portuguesa De Pneumologia (English Edition), 20(2), 84-91. http://dx.doi.org/10.1016/j.rppnen.2013.06.007


Stessuk, T., Ruiz, M., Greco, O., Bilaqui, A., Ribeiro-Paes, M., & Ribeiro-Paes, J. (2013). Phase I clinical trial of cell therapy in patients with advanced chronic obstructive pulmonary disease: follow-up of up to 3 years. Revista Brasileira De Hematologia E Hemoterapia, 35(5). http://dx.doi.org/10.5581/1516-8484.20130113


Inamdar, A. & Inamdar, A. (2013). Mesenchymal stem cell therapy in lung disorders: Pathogenesis of lung diseases and mechanism of action of mesenchymal stem cell. Experimental Lung Research, 39(8), 315-327. http://dx.doi.org/10.3109/01902148.2013.816803