Macular Degeneration

 

Macular Degeneration is caused by the deterioration of the central portion of the retina, the inside back layer of the eye that records the images we see and sends them via the optic nerve from the eye to the brain. The retina’s central portion, known as the macula, is responsible for focusing central vision in the eye, and it controls our ability to read, drive a car, recognize faces or colors, and see objects in fine detail.


How can Stem Cells Help Macular Degeneration?

Adipose stem cell therapy is an alternative to help manage the complications of degenerative diseases. The stem cells have the potential to replace countless cells of the body. Adipose stem cells can be differentiated to retinal pigment epithelium cells and can potentially replace damage tissue in the affected macular.


How are Mesenchymal Stem Cells (MSC) administered in Macular Degeneration?

A typical treatment is as following; stem cells are administered by a license physician.

Depending of the severity of the case could be administered intravenous, retrobulbar.


Which Kinds of cells are used in Macular Degeneration and how are they obtained?

Adult stem cells are obtained from ITC bank from donor tissue or autologous transplant, which is harvested from the patient’s own adipose tissue and it takes 21 days to culture, differentiate and administer the adult stem cells to the patient.


Vossmerbaeumer, U., Ohnesorge, S., Kuehl, S., Haapalahti, M., Kluter, H., & Jonas, J. et al. (2009). Retinal pigment epithelial phenotype induced in human adipose tissue-derived mesenchymal stromal cells. Cytotherapy, 11(2), 177-188. http://dx.doi.org/10.1080/14653240802714819


Melville, H., Carpiniello, M., Hollis, K., Staffaroni, A., & Golestaneh, N. (2013). Stem cells: a new paradigm for disease modeling and developing therapies for age-related macular degeneration. Journal Of Translational Medicine, 11(1), 53. http://dx.doi.org/10.1186/1479-5876-11-53


Otani, A., Kinder, K., Ewalt, K., Otero, F., Schimmel, P., & Friedlander, M. (2002). Bone marrow–derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nature Medicine, 8(9), 1004-1010. http://dx.doi.org/10.1038/nm744


Otani, A., Dorrell, M., Kinder, K., Moreno, S., Nusinowitz, S., & Banin, E. et al. (2004). Rescue of retinal degeneration by intravitreally injected adult bone marrow–derived lineage-negative hematopoietic stem cells. Journal Of Clinical Investigation, 114(6), 765-774. http://dx.doi.org/10.1172/jci200421686